HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → HCID 11287643, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | 1,3-Dimethyl 2-(4-pyridinylmethylene)propanedioate | HCID 12057009 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 11287643 | HCID 11287643 | — |
Reaction Steps
A solution of dimethyl (4-pyridylmethylene)malonate [XXVIIIa] (925 g) in methanol (9 L) was hydrogenated in the presence of glacial acetic acid (360 mL) and 10% palladium on activated carbon catalyst (92.5 g) at 60° C. and 200 psi. The catalyst was filtered off and the resulting solution of the title compound in the form of acetic acid salt was used directly in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06492522B1 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-26afa65d638d4deba309efa9ae0b00e1 |
| Source note | uspto-grants-2002_12 |