HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-1-(3,4-dimethoxyphenyl)ethan-1-one → Methyl 4-[4-(3,4-dimethoxyphenyl)(1,3-thiazol-2-yl)]-5-methylthiothiophene-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-1-(3,4-dimethoxyphenyl)ethan-1-one | HCID 270423 | — |
| Reactant | Methyl 4-(aminothioxomethyl)-5-methylthiothiophene-2-carboxylate | HCID 86583815 | — |
| Product | Methyl 4-[4-(3,4-dimethoxyphenyl)(1,3-thiazol-2-yl)]-5-methylthiothiophene-2-carboxylate | HCID 86583813 | 89.2% |
Reaction Steps
105 mg (0.424 mmol) of methyl 4-(aminothioxomethyl)-5-methylthiothiophene-2-carboxylate (Maybridge Chemical Co. LTD., Cornwall, U.K.) was reacted with 1-(3,4-dimethoxyphenyl)-2-bromoethan-1-one (0.467 mmol; 120 mg) in a manner similar to Example 22, step (a) to afford 148 mg (85% yield) of methyl 4-[4-(3,4-dimethoxyphenyl)(1,3-thiazol-2-yl)]-5-methylthiothiophene-2-carboxylate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06492403B1 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-9fdc63c0c62f479c806dd07e88fb9516 |
| Source note | uspto-grants-2002_12 |