HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Phenoxyphenylthiourea → Methyl 4-(2-{[4-(phenoxy)phenyl]amino}(1,3-thiazol-4-yl))-5-methylthiothiophene-2-carboxylate hydrobromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Phenoxyphenylthiourea | HCID 2760349 | — |
| Reactant | Methyl 4-(2-bromoacetyl)-5-methylthiothiophene-2-carboxylate | HCID 86583828 | — |
| Product | Methyl 4-(2-{[4-(phenoxy)phenyl]amino}(1,3-thiazol-4-yl))-5-methylthiothiophene-2-carboxylate hydrobromide | HCID 86758183 | 90.2% |
Reaction Steps
Methyl 4-(2-bromoacetyl)-5-methylthiothiophene-2-carboxylate (200 mg, 0.64 mmol) was allowed to react with 4-phenoxyphenylthiourea (158 mg) as described in Example 154, step (a) to give 300 mg (88% yield) of methyl 4-(2-{[4-(phenoxy)phenyl]amino}(1,3-thiazol-4-yl))-5-methylthiothiophene-2-carboxylate hydrobromide. Mass Spectrum (ESI) m/z calcd. for C22H18N2O3S3, 454.6 (M+H), found 455.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06492403B1 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-c8bd5b0fd00b41e9883670c8443abd5d |
| Source note | uspto-grants-2002_12 |