HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(3,4,5-Trimethoxyphenyl)thiourea → Isopropyl 5-methyl-4-{2-[(3,4,5-trimethoxyphenyl)amino](1,3-thiazol-4-yl)}thiophene-2-carboxylate hydrobromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(3,4,5-Trimethoxyphenyl)thiourea | HCID 2760811 | — |
| Reactant | Isopropyl 4-(2-bromoacetyl)-5-methylthiophene-2-carboxylate | HCID 18537306 | — |
| Product | Isopropyl 5-methyl-4-{2-[(3,4,5-trimethoxyphenyl)amino](1,3-thiazol-4-yl)}thiophene-2-carboxylate hydrobromide | HCID 18536836 | 48% |
Reaction Steps
Isopropyl-4-(2-bromoacetyl)-5-methylthiophene-2-carboxylate (84 mg, 0.27 mmol) was allowed to react with 3,4,5-trimethoxyphenylthiourea (66.5 mg) as described in Example 154, step (a) to give 68 mg (48% yield) of isopropyl 5-methyl-4-{2-[(3,4,5-trimethoxyphenyl)amino](1,3-thiazol-4-yl)}thiophene-2-carboxylate hydrobromide. Mass Spectrum (ESI) m/z calcd. For C21H24N2O5S2, 448.56 (M+H), found 449.0.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06492403B1 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-69c41590839648fd9cca6f6727d16429 |
| Source note | uspto-grants-2002_12 |