HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl acetoacetate → 5-(2-Fluoro-5-trifluoromethyl-phenyl)-2-methyl-1-[(R)-1-(tetrahydro-furan-2-yl)methyl]-1H-pyrrole-3-carboxylic acid cyclohexylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl acetoacetate | HCID 7757 | — |
| Reactant | Cyclohexylamine | HCID 7965 | — |
| Reactant | (R)-(-)-Tetrahydrofurfurylamine | HCID 2734124 | — |
| Reactant | 2-Fluoro-5-(trifluoromethyl)phenacyl bromide | HCID 2778784 | — |
| Product | 5-(2-Fluoro-5-trifluoromethyl-phenyl)-2-methyl-1-[(R)-1-(tetrahydro-furan-2-yl)methyl]-1H-pyrrole-3-carboxylic acid cyclohexylamide | HCID 11719393 | — |
Reaction Steps
The title compound was synthesized in analogy to example 7, using 3-oxo-butyric acid methyl ester as compound of formula R, 2-bromo-1-[2-fluoro-5-(trifluoromethyl)-phenyl]-ethanone as compound of formula S, (R)-tetrahydrofurfurylamine as R3—(CH2)m—NH2 and cyclohexylamine as R1R2NH, MS (ISP) 453.6 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07563910B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-9d94c12581484394aed0c0f6b34f563a |
| Source note | uspto-grants-2009_07 |