HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl acetoacetate → 2-[5-(5-Chloro-2-fluoro-phenyl)-3-cyclohexylcarbamoyl-2-methyl-pyrrol-1-ylmethyl]-pyrrolidine-1-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl acetoacetate | HCID 7757 | — |
| Reactant | Cyclohexylamine | HCID 7965 | — |
| Reactant | tert-butyl (2R)-2-(aminomethyl)pyrrolidine-1-carboxylate | HCID 1512534 | — |
| Reactant | 2-Bromo-1-(5-chloro-2-fluorophenyl)ethanone | HCID 79021921 | — |
| Product | 2-[5-(5-Chloro-2-fluoro-phenyl)-3-cyclohexylcarbamoyl-2-methyl-pyrrol-1-ylmethyl]-pyrrolidine-1-carboxylic acid tert-butyl ester | HCID 11692086 | — |
Reaction Steps
The title compound was synthesized in analogy to example 7, using 3-oxo-butyric acid methyl ester as compound of formula R, 2-bromo-1-[2-fluoro-5-chlorophenyl]-ethanone as compound of formula S, (R)-2-aminomethyl-pyrrolidine-1-carboxylic acid tert-butyl ester as R3—(CH2)m—NH2 and cyclohexylamine as R1R2NH, MS (ISP) 518.3 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07563910B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-67035d2272a7413bb78c3ff9a6709651 |
| Source note | uspto-grants-2009_07 |