tert-Butyl methyl ether → HCID 88151757, compound

Participants

Reaction Steps

A stirred mixture of 1-methyl-1H-pyrimidine-2-thione (2.76 g, 0.0219 mol) and N-[4-(2-bromo-ethylsulfamoyl)-phenyl]-3-(3,5-di-tert-butyl-4-hydroxy-phenyl)-propionamide (9.98 g, 0.0185 mol) in 1-propanol (25 ml) was heated at reflux for 2.5 hours. The mixture was spin-evaporated in vacuo to give a solid residue. The residue was dissolved in ethyl acetate (200 g) and mixed with tert.-butyl-methyl ether (20 g) to give two liquid phases. The lower phase was concentrated in vacuo to give2-(2-{4-[3-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-propionylamino]-benzenesulfonylamino} -ethylsulfanyl)-1-methyl-pyrimidin-1-ium bromide.

Provenance & Evidence