HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl acetoacetate → (Rac)-5-(2-chloro-5-trifluoromethyl-phenyl)-1-[1,4]dioxan-2-ylmethyl-2-methyl-1h-pyrrole-3-carboxylic acid cyclohexylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl acetoacetate | HCID 7757 | — |
| Reactant | Cyclohexylamine | HCID 7965 | — |
| Reactant | 2-Chloro-5-(trifluoromethyl)phenacyl bromide | HCID 2783183 | — |
| Reactant | 1,4-Dioxan-2-ylmethanamine | HCID 3748064 | — |
| Product | (Rac)-5-(2-chloro-5-trifluoromethyl-phenyl)-1-[1,4]dioxan-2-ylmethyl-2-methyl-1h-pyrrole-3-carboxylic acid cyclohexylamide | HCID 11677461 | — |
Reaction Steps
The title compound was synthesized in analogy to example 7, using 3-oxo-butyric acid methyl ester as compound of formula R, 2-bromo-1-[2-chloro-5-(trifluoromethyl)-phenyl]-ethanone as compound of formula S, 1,4-dioxane-2-methanamine as R3—(CH2)m—NH2 and cyclohexylamine as R1R2NH, MS (ISP) 485.5 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07563910B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-1df8192974834111968a5eb183ff64a9 |
| Source note | uspto-grants-2009_07 |