Sodium Hydroxide → HCID 18378701, compound

Participants

Reaction Conditions

Reaction Steps

140 μl (2.9 mmol) of hydrazine hydrate and 80 mg (2 mmol) of sodium hydroxide are added to a solution of 200 mg (0.6 mmol) of the compound obtained in Step B in 2 ml of diethylene glycol. After 24 hours' stirring at 160° C., the mixture is hydrolysed and then extracted with ethyl acetate. The organic phase is washed several times with water, dried over magnesium sulphate, concentrated and then purified by flash chromatography over silica gel (eluant: petroleum ether/ethyl acetate, 7:3) to yield the title compound in the form of a yellow oil.

Provenance & Evidence