HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl acetoacetate → 5-(2-Chloro-5-trifluoromethyl-phenyl)-1-(rac)-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-2-methyl-1h-pyrrole-3-carboxylic acid ((1r,2r)-2-hydroxy-cyclohexyl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl acetoacetate | HCID 7757 | — |
| Reactant | (1R,2R)-2-Aminocyclohexanol | HCID 735777 | — |
| Reactant | 2-Chloro-5-(trifluoromethyl)phenacyl bromide | HCID 2783183 | — |
| Reactant | 1,3-Dioxolane-4-methanamine, 2,2-dimethyl- | HCID 4122349 | — |
| Product | 5-(2-Chloro-5-trifluoromethyl-phenyl)-1-(rac)-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-2-methyl-1h-pyrrole-3-carboxylic acid ((1r,2r)-2-hydroxy-cyclohexyl)-amide | HCID 11634924 | — |
Reaction Steps
The title compound was synthesized in analogy to example 7, using 3-oxo-butyric acid methyl ester as compound of formula R, 2-bromo-1-[2-chloro-5-(trifluoromethyl)-phenyl]-ethanone as compound of formula S, 2,2-dimethyl-1,3-dioxolan-4-methylamine as R3—(CH2)m—NH2 and (1R,2R)-2-aminocyclohexanol as R1R2NH, MS (ISP) 515.4 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07563910B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-bbca0afc467e4c98838acb70ebb7ef43 |
| Source note | uspto-grants-2009_07 |