HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydroxylamine HCl → 5-Nitro-benzimidazole-2-carboxamide oxime
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydroxylamine HCl | HCID 21645 | — |
| Reactant | Sodium Acetate | HCID 517045 | — |
| Reactant | 5-nitro-1H-benzo[d]imidazole-2-carbonitrile | HCID 21722891 | — |
| Solvent | Water ethanol | HCID 19096565 | — |
| Product | 5-Nitro-benzimidazole-2-carboxamide oxime | HCID 136003076 | 68.1% |
Reaction Steps
2 g of 5-nitrobenzimidazole-2-carbonitrile (Lopyrev, V. A.; Larina, L. I.; Baumane, L. Kh.; Shibanova, E. F.; Gavar, R. A.; et al., Chem. Heterocycl. Compd. (Engl. Transl.), EN, 20, 9, 1984, 1021-1026, KGSSAQ, RU, 20, 9, 1984, 1246-1251) are dissolved in 60 ml of ethanol/water (5/1) and treated with 0.74 g of hydroxyl-ammonium chloride and also 1.05 g of sodium acetate and refluxed for 2 h. The mixture is poured into ice water, and the brown precipitate is filtered off with suction and washed with water. 1.6 g of the title compound are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06495545B1 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-137510983acf4b7f9f0af7f79d250177 |
| Source note | uspto-grants-2002_12 |