HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclopropylamine → tert-Butyl 3-(cyclopropylamino)methyl-4-nitrobenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclopropylamine | HCID 69828 | — |
| Reactant | Tert-butyl 3-(bromomethyl)-4-nitrobenzoate | HCID 10335882 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | tert-Butyl 3-(cyclopropylamino)methyl-4-nitrobenzoate | HCID 18378719 | 86.7% |
Reaction Steps
23.7 g of tert-butyl 3-(bromomethyl)-4-nitrobenzoate are suspended in 400 ml of EtOH and treated at 0° C. with 9.0 g of cyclopropylamine. The mixture is stirred for 24 h, concentrated, and the residue is crystallized from petroleum ether. The mother liquor is chromatographed and crystallized. 19 g of the title compound are obtained. MS (DCI) 293 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06495545B1 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-0c0dd6fa739947dc9f733b90080b0c18 |
| Source note | uspto-grants-2002_12 |