Tetrabutylammonium Fluoride → HCID 18378600, compound

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Reaction Steps

A mixture of 2-methoxy-N-(2-tert-butyldimethylsiloxymethyl-1H-benzimidazol-4-yl)-4-(2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)carbonylbenzamide (250 mg) and tetrabutylammonium fluoride (1 mol solution in tetrahydrofuran 0.9 ml) in tetrahydrofuran (15 ml) was stirred at room temperature for 4 hours, and the solvent was removed by evaporation. The residue was purified by silica gel column chromatography (1% methanol in chloroform) to give 2-methoxy-N-(2-hydroxymethyl-1H-benzimidazol-4-yl)-4-(2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)carbonylbenzamide (125 mg).

Provenance & Evidence