Potassium Carbonate → HCID 11657071, compound

Participants

Reaction Steps

To a solution of acetic acid 3-({5-(2,5-bis-trifluoromethyl-phenyl)-2-methyl-1-[(R)-1-(tetrahydro-furan-2-yl)methyl]-1H-pyrrole-3-carbonyl}-amino)-1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl ester (60 mg) in MeOH (2 mL) was added 15 μL of a 1N K2CO3 solution. After 18 hours the reaction mixture was extracted with ethyl acetate and the organic phases were washed with brine, dried over sodium sulfate and filtered. Removal of the volatiles in vacuo and chromatography of the crude residue afforded the title compound (54 mg), MS (ISP) 631.5 (M+H)+.

Provenance & Evidence