Methanol → HCID 86596485, compound

HRID 229887Notes

Reaction equation

[CH3:1][OH:2].[S:3](=[O:7])(=[O:6])([OH:5])[OH:4].[CH:8]([Cl:11])([Cl:10])[Cl:9]>>[CH:8]([Cl:11])([Cl:10])[Cl:9].[CH3:1][OH:2].[S:3](=[O:5])(=[O:4])([OH:7])[OH:6]

Participants

Reactant 3

HCID 887Methanol

HCID 1118Sulfuric Acid

HCID 6212Chloroform

Product 1

HCID 86596485HCID 86596485, compound

Procedure

A colorless solid (yield: 91.0%) was obtained through reaction conducted as in example 54 except that the reactants were replaced by the compound (123) prepared in example 23 (0.5 g), methanol (42.7 mL), chloroform (42.7 mL) and sulfuric acid (36 N, 0.26 mL), the reaction temperature was lowered to room temperature, and the reaction time was extended to 72 hours. 1H-NMR data showed that the product consisted of a compound (144) and the compound (123) (content of compound (144): 81.5 mol %).

Workup

customwas lowered to room temperature

Sources & evidence

ORD record: ord-9e3859d5839b4aa4a0f04de461525c3e
Source dataset: uspto-grants-2009_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07563917B2

Reaction notes

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