Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Carbonate → 3,4-dihydrobenzothieno[2,3-c]-pyridine-2(1H)-butanenitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | 4-Chlorobutyronitrile | HCID 12336 | — |
| 반응물 | 1,2,3,4-Tetrahydro[1]benzothieno[2,3-c]pyridine | HCID 413282 | — |
| 용매 | Toluene | HCID 1140 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 3,4-dihydrobenzothieno[2,3-c]-pyridine-2(1H)-butanenitrile | HCID 18378958 | 101.4% |
반응 단계
A mixture of 1,2,3,4-tetrahydro-[1]benzothieno[2,3-c]pyridine (0.02 mol), Na2CO3 (5 g), KI (0.1 g) and 4-chlorobutanenitrile (0.025 mol) in acetonitrile (50 ml) and methylbenzene (150 ml) was stirred and refluxed overnight, then cooled, filtered and the filtrate was evaporated. The residue (oil) was purified by column chromatography over silica gel (eluent: CH2Cl2/CH3OH 98/2). The pure fractions were collected and the solvent was evaporated, yielding 5.2 g of 3,4-dihydrobenzothieno[2,3-c]-pyridine-2(1H)-butanenitrile (interm. 6).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06495555B1 |
| 출처 데이터셋 | uspto-grants-2002_12 |
| ORD ID | ord-fde6fc8e3ab44b2f98e46e198b471392 |
| 출처 메모 | uspto-grants-2002_12 |