Sodium Carbonate → HCID 86758703, compound

Participants

Reaction Steps

A mixture of 1,2,3,4-tetrahydro-benzofuro[2,3-c]pyridine hydrochloride (1:1) (0.007 mol), 3-(2-chloroethyl)-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one(0.012 mol), Na2CO3 (0.015 mol) and KI (catalytic quantity) in 2-butanone (100 ml) was stirred and refluxed overnight. The reaction mixture was filtered hot and the filtrate was evaporated. The residue was purified by column chromatography over silica gel (eluent: CH2Cl2/(CH3OH/NH3) from 98/2 to 97/3). The purest fractions were collected and the solvent was evaporated. The residue was dissolved in 2-propanol and (E)-2-butenedioic acid (1 g) was added. The mixture was boiled and then stirred at RT. The precipitate was filtered off and dried, yielding 2.00 g (61%) of 3-[2-(3,4-dihydro-benzofuro[2,3-c]pyridin-2(1H)-yl)ethyl]-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one (E)-2-butenedioate (2:1) (compound 1).

Provenance & Evidence