Lithium Hydroxide → HCID 18378997, compound

Participants

Reaction Conditions

Reaction Steps

The cis/trans mixture of 4-(1H-imidazo[4,5-b]pyridin-2-ylmethyl)-cyclohexanecarboxylic acid ethyl ester (Compound AAA) (1 g) was dissolved in a minimal amount of TBF (10 mL) and mixed with concentrated aqueous LiOH (5 mL). The resulting reaction mixture was stirred vigorously and heated at 65° C. for 3 h. After cooling and concentration, the reaction was acidified to pH 4 with dilute HCl and concentrated to dryness: mass spectrum m/z 260 [(M+H)+; calcd for C14H 18N3O2: 259].

Provenance & Evidence