Benzyloxyamine hydrochloride → HCID 86758705, compound

Participants

Reaction Steps

3-{6-[(4-Chloro-phenyl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-1-methyl-2-oxo-1,2-dihydro-quinolin-4-yl}-benzaldehyde (202 mg, 0.418 mMol) was dissolved in a solution of DCM (2.0 mL) and MeOH (2.0 mL) under an atmosphere of dry N2. To this solution was added O-benzylhydroxylamine hydrochloride (66.8 mg, 418 mMol) and the mixture was stirred for 24 hours at ambient temperature. The reaction mixture was concentrated under vacuum and was purified by radial chromatography eluting with MeOH/EtOAc/NH4OH (5:95:0.1) to give the titled compound as an oil.

Provenance & Evidence