反应详情

N-[(5S)-3-(3-Fluoro-4-(4-hydroxymethylimidazol-1-yl)phenyl)-2-oxooxazolidin-5-yl-methyl]acetamide (174 mg, 0.5 mM) and pyrimidine-2-thione (112 mg, 1 mM) were suspended in dry acetonitrile (20 ml), and N,N-dimethylformamide dineopentyl acetal (462 mg, 2 mM) added. The mixture was heated to reflux for 6 hours giving a solution. Solvent was evaporated, the residue dissolved in dichloromethane, and subjected to mplc on silica, eluting with a gradient increasing in polarity from 0 to 20% methanol in dichloromethane. Relevant fractions were combined and evaporated to give the title product (204 mg) as a gum.

1. temperatureThe mixture was heated
2. temperatureto reflux for 6 hours
3. customgiving a solution
4. customSolvent was evaporated
5. dissolutionthe residue dissolved in dichloromethane
6. washeluting with
7. temperaturea gradient increasing in polarity from 0 to 20% methanol in dichloromethane
8. customevaporated