N-[(5S)-3-(3-Fluoro-4-(4-azidomethylimidazol-1-yl)phenyl)-2-oxooxazolidin-5-yl-methyl]acetamide → N-[(5S)-3-(3-Fluoro-4-(4-aminomethylimidazol-1-yl)phenyl)-2-oxooxazolidin-5-yl-methyl]acetamide

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Reaction Steps

N-[(5S)-3-(3-Fluoro-4-(4-azidomethylimidazol-1-yl)phenyl)-2-oxooxazolidin-5-yl-methyl]acetamide (1.38 g, 3.67 mM) was dissolved in ethanol (60 ml), treated with Lindlar catalyst (5% Pd on CaCO3 partially poisoned with lead, 650 mg), and stirred under an atmosphere of hydrogen under balloon pressure for 4 hours. After filtration through celite, solvent was evaporated to give the title product as a gum, pure enough for further work (1.3 g).

Provenance & Evidence