Benzo(d)thiazol-2-amine → HCID 86758702, compound

Participants

Reaction Steps

N-[(5S)-3-(3-Fluoro-4-(4-carboxyimidazol-1-yl)phenyl)-2-oxooxazolidin-5-ylmethyl]acetamide (1.81 g, 5 mM) and 1-hydroxybenzotriazole (0.81 g, 6 mM) were dissolved in DMF (40 ml) and stirred under nitrogen at ambient temperature. 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide methiodide (1.78 g, 6 mM) was added, and the mixture stirred at ambient temperature for 2 hours, before adding 2-aminobenzothiazole (0.75 g, 5 mM). After stirring for 5 days, the mixture was diluted slowly with saturated aqueous sodium bicarbonate solution (20 ml), then water added to 250 ml. The fine precipitate was filtered, and recrystallised from a mixture of acetic acid (30 ml) and water (20 ml) to give title product (1 g).

Provenance & Evidence