(+-)-2-Butanol → Ibandronate Sodium Anhydrous

Participants

Reaction Steps

A solution of amorphous ibandronic acid (4.5 g) in water (20 ml) and 1 N aqueous sodium hydroxide (14 ml) was stirred at room temperature to obtain a pH of 3.5. The solution was added dropwise into 2-butanol (100 ml) while stirring. The obtained precipitate was stirred at room temperature for 16 hours. The precipitate was isolated by vacuum filtration, washed with 2-butanol (2×20 ml), and dried in a vacuum oven at 50° C. for 24 hours to obtain 4.4 g of ibandronate sodium crystal form Q2.

Provenance & Evidence