Diethyl squarate → HCID 18379722, compound

Participants

Reaction Steps

A solution of the product from Example 52A (2.98 g, 18.4 mmol) and 3,4,-diethoxy-3-cyclobutene-1,2-dione (3.13 g, 18.4 mmol) in EtOH (50 mL) was heated at reflux for 48 hours. The reaction mixture was filtered while still hot and the filtrate was absorbed onto silica gel. The crude material was purified by chromatography, eluting with EtOAc/hexanes (3:1) to provide 2.00 g (38% yield) of the desired compound as colorless crystals.

Provenance & Evidence