関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | Bromine | HCID 24408 | — |
| 反応物 | 1-Methyl-1H-benzimidazol-6-amine | HCID 13680283 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 3-Methyl-4-bromo-5-aminobenzimidazole | HCID 12968452 | 35% |
反応手順
To a solution of 3-methyl-5-aminobenzimidazole (0.27 g, 1.8 mmol) in 10 ml of AcOH was added Br2 (0.10 ml). The reaction mixture was stirred for 1 h at 25° C. and concentrated in vacuo, yielding an oil which was subjected to column chromatography (NH3 sat'd 3% MeOH/CHCl3) to yield 0.14 g (0.62 mmol, 35%) of the desired product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06495583B1 |
|---|
| 出典データセット | uspto-grants-2002_12 |
|---|
| ORD ID | ord-5fd852d0bb6643d6911bf374c2769674 |
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| 出典メモ | uspto-grants-2002_12 |
|---|
