Sodium Hydroxide → Ibandronate Sodium Anhydrous

Participants

Reaction Steps

A solution of amorphous ibandronic acid (5 g) in aqueous ethanol 96% (70 ml) was stirred at reflux temperature. Solid sodium hydroxide (0.63 g) was added. The obtained precipitate was cooled to room temperature and stirred for an additional 20 hours. The precipitate was isolated by vacuum filtration, washed with aqueous ethanol 96% (2×10 ml) and dried in a vacuum oven at 50° C. for 24 hours to obtain 6.0 g of ibandronate sodium crystal form Q6. Form Q6 can exhibit a weight loss of about 9% to about 10% in TGA.

Provenance & Evidence