HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 1-Isopropyl-4-iodo-5-aminobenzimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Iodine | HCID 807 | — |
| Reactant | 1-Isopropyl-1H-benzoimidazol-5-ylamine | HCID 16244162 | — |
| Reactant | Dichloromethane methanol | HCID 21226129 | — |
| Catalyst | Diacetyloxymercury | HCID 16683746 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 1-Isopropyl-4-iodo-5-aminobenzimidazole | HCID 18379852 | 35% |
Reaction Steps
To a solution of 1-isopropyl-5-aminobenzimidazole (0.70 g, 3.7 mmol) and Hg(OAc)2 (2.1 g, 5.6 mmol) in 10 ml of AcOH was added solution of I2 in ACOH until it produces a precipitation; The reaction mixture was concentrated in vacuo to provide a brown solid which was subjected to column chromatography (5% NH3 sat'd MeOH/CH2Cl2) to provide 0.40 g (1.3 mmol, 35%) of the product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06495583B1 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-6784b1776ddb4dacb3a23f00c9116701 |
| Source note | uspto-grants-2002_12 |