Ammonia → HCID 18379813, compound

HRID 2299133Notes

Reaction equation

HRID 2299133 reaction equation
[CH:1]1([N:6]2[C:10]3[CH:11]=[CH:12][C:13]([NH2:15])=[CH:14][C:9]=3[N:8]=[CH:7]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[Br:16]Br.N>CO.C(Cl)Cl>[CH:1]1([N:6]2[C:10]3[CH:11]=[CH:12][C:13]([NH2:15])=[C:14]([Br:16])[C:9]=3[N:8]=[CH:7]2)[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

5

Reactant 3

HCID 222AmmoniaHCID 24408BromineHCID 18379865HCID 18379865, compound

Product 1

HCID 18379813HCID 18379813, compoundYield 35%

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

To a solution of 1-cyclopentyl-5-aminobenzimidazole (1.1 g, 5.5 mmol) in 20 ml of ACOH was added solution of Br2 in. ACOH until it produces a precipitation. The reaction mixture was concentrated in vacuo to provide a brown solid which was subjected to column chromatography (5% NH3 sat'd MeOH/CH2Cl2) to provide 0.54 g (1.9 mmol, 35%) of the product.

Workup

  1. customACOH until it produces
  2. customa precipitation
  3. concentrationThe reaction mixture was concentrated in vacuo
  4. customto provide a brown solid which

Sources & evidence

ORD record
ord-dbf64bbaa85e44c3aca9c18fc480c6ac
Source dataset
uspto-grants-2002_12
Patent number
US06495583B1

Reaction notes

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