Sodium Hydroxide → Ibandronate Sodium Anhydrous

Participants

Reaction Steps

A solution of sodium hydroxide (0.63 g) in water (12.5 ml) was added dropwise to a slurry of amorphous ibandronic acid (5 g) in ethanol (70 ml) at reflux temperature. Then the solution was cooled to room temperature and stirred for 72 hours to obtain a pH of 4.15. The precipitate was isolated by vacuum filtration, washed with ethanol (2×25 ml), and dried in a vacuum oven at 50° C. for 23 hours to obtain 4.97 g of ibandronate sodium crystal form QQ.

Provenance & Evidence