Sodium Hydroxide → Ibandronate Sodium Anhydrous

Participants

Reaction Steps

A solution of sodium hydroxide (0.63 g) in ethanol (14 ml) was added dropwise to a solution of ibandronic acid (5 g) in water (50 ml) at room temperature. The obtained slurry was stirred for 3 hours to obtain a pH of 4.1. The precipitate was isolated by vacuum filtration, washed with ethanol (2×25 ml) and dried in a vacuum oven at 50° C. for 22 hours to obtain 5.4 g of ibandronate sodium crystal form QQ.

Provenance & Evidence