Sodium Hydroxide → HCID 23684386, compound

Participants

Reaction Conditions

Reaction Steps

A solution of ethyl 6-[N-(2, 4-difluorophenyl)sulfamoyl]-1-cyclohexene-1-carboxylate obtained in Example 3 (Compound 3, 2.5 g) in acetonitrile (288 ml) was admixed with a 1N aqueous solution of sodium hydroxide (228 ml) and the mixture was stirred at 55° C. for 12 hours. The mixture was concentrated under reduced pressure and the residue was purified by CHP-20P column chromatography (eluent: water→methanol/water=1/1). The eluent was concentrated under reduced pressure and the residue was dissolved in water (10 ml) and lyophilized to yield sodium 6-[N-(2,4-difluorophenyl)sulfamoyl]-1-cyclohexene-1-carboxylate (0.50 g) as white crystals.

Provenance & Evidence