Hydrochloric Acid → HCID 21958070, compound

Participants

Reaction Steps

Ethyl 6-[N-[2-chloro-4-(N-t-butoxycarbonylmethylcarbamoyl)phenyl]sulfamoyl]-1-cyclohexene-1-carboxylate (23 mg) was dissolved in ethyl acetate (0.5 ml) and then admixed with a 4N solution of hydrogen chloride in ethyl acetate (1.8 ml) and the mixture was stirred at room temperature for 51 hours. The reaction mixture was diluted with ethyl acetate and then washed twice with saturated brine. The ethyl acetate layer was dried over magnesium sulfate and the solvent was distilled off under reduced pressure. The residue was purified by column chromatography on silica gel (eluent: ethyl acetate/hexane=11:14) to yield ethyl 6-[N-[2-chloro-4-(N-ethoxycarbonylmethylcarbamoyl)phenyl]sulfamoyl]-1-cyclohexene-1-carboxylate (Compound 63; 18 mg) as a colorless oil.

Provenance & Evidence