Benzyl Alcohol → HCID 86183876, compound

Participants

Reaction Steps

According to the above synthetic scheme, first, 18.1 g of aminobutyric acid, 87.5 ml of benzyl alcohol and 40.0 g of p-toluenesulfonic acid were dissolved in 175 ml of benzene and refluxed. The water formed was removed as the azeotrope with benzene. To the reaction solution were added 280 ml of diethyl ether and 280 ml of hexane to form a precipitate. This precipitate was separated by filtration and recystallized in an ether/ethanol mixed solution to effect purification. As a result, 53.8 mg of β-aminobutyric acid benzyl ester·p-toluenesulfonate were obtained as a white crystal. From the results of 1H-NMR spectrometry the synthesis of β-aminobutyric acid benzyl ester·p-toluenesulfonate was confirmed. The results of the 1H-NMR spectrometry are set forth below. The underlined portion shows the position of the corresponding proton in the compound. Further, in the NMR data, “Φ-” shows a phenyl group.

Provenance & Evidence