Triethylamine → HCID 70189270, compound

Participants

Reaction Steps

Next, 50 g of β-aminobutyric acid benzyl ester·p-toluenesulfonate were dispersed in 300 ml of ether containing 54.3 ml of triethylamine. To this dispersion were slowly added 12.7 ml of acryloyl chloride at 0° C. and stirred for 2 hours. The ether layer was recovered, condensed and purified by silica gel chromatography to obtain 19.59 g of the desired 2-(benzyloxycarbonyl)isopropyl acrylamide as a white crystal. The synthesis was confirmed by 1H-NMR spectrometry and elementary analysis. The results of the 1H-NMR spectrometry and the elementary analysis are set forth below. The underlined portion shows the position of the corresponding proton in the compound.

Provenance & Evidence