Acetic Acid Mixture with Hydrobromic Acid → HCID 86758708, compound

Participants

Reaction Steps

In a hydrogen bromide acetic acid solution was dispersed 1 g of the 2-(benzyloxycarbonyl)aminoisopropyl acrylamide synthesized in Example 8 and stirred for two hours. After hydrogen bromide and acetic acid were thoroughly distilled off, water was added to the residue. The protective group benzyl bromide eliminated with the use of ether was removed by extraction and subsequently, the aqueous layer was concentrated. Methanol was added to the residue and stirred for two hours. Only the methanol layer was separated and condensed to obtain the desired 2-aminoisopropyl acrylamide hydrobromate as a white solid. The structure was confirmed by using 1H-NMR.

Provenance & Evidence