HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → Ibandronate Sodium Anhydrous
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Ibandronate | HCID 60852 | — |
| Solvent | Propan-2-ol--water (1/1) | HCID 21889133 | — |
| Product | Ibandronate Sodium Anhydrous | HCID 23670359 | 110.4% |
Reaction Steps
A solution of sodium hydroxide (0.63 g) in water:IPA (80:20 v/v, 38 ml) was added dropwise to a solution of amorphous ibandronic acid (5 g) in water:IPA (80:20 v/v, 212 ml) at reflux temperature. The reaction mixture was heated at reflux temperature for an additional 45 minutes. Then the reaction mixture was cooled to room temperature. The clear solution was evaporated until dry to give 5.9 g of amorphous ibandronate sodium.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07563918B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-69110b84e5e940a2bc10f0d8fb30a86e |
| Source note | uspto-grants-2009_07 |