HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → Ibandronate Sodium Anhydrous
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Ibandronate | HCID 60852 | — |
| Solvent | Acetonitrile--water (1/1) | HCID 18373917 | — |
| Product | Ibandronate Sodium Anhydrous | HCID 23670359 | 121.6% |
Reaction Steps
A solution of sodium hydroxide (0.55 g) in water:acetonitrile (80:20 v/v, 33 ml) was added dropwise to a solution of amorphous ibandronic acid (4 g) in water:acetonitrile (80:20 v/v, 187 ml) at reflux temperature. Then the reaction mixture was cooled to room temperature. The clear solution was evaporated until dry to obtain 5.2 g of amorphous ibandronate sodium.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07563918B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-35c373a617964823b53de7e61fd11913 |
| Source note | uspto-grants-2009_07 |