HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ticlopidine → HCID 12570081, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ticlopidine | HCID 5472 | — |
| Reactant | 2-Chlorobenzylamine | HCID 66648 | — |
| Reactant | Thiophene, 2-oxiranyl- | HCID 10866336 | — |
| Product | HCID 12570081 | HCID 12570081 | — |
Reaction Steps
Literature precedent for ticlopidine (J. P. Maffrand, R. Boigegrain, Heterocycles, 1979, 12, 1479; FR 2,424,278) shows that (2-thienyl)ethylene oxide 14 reacts with o-chlorobenzylamine to provide the desired N-(2-(2-thienyl)-2-hydroxyethyl)-o-chlorobenzylamine in low yield due to lack of regioselectivity in the epoxide ring opening (Scheme 5).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06495691B1 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-5430097adf0d4b4f94f3ebcac760c750 |
| Source note | uspto-grants-2002_12 |