Ammonia → 2,3,5,6-Tetramethylpyridine

HRID 2299279Notes

Reaction equation

HRID 2299279 reaction equation
C=O.N.[N:4]1[CH:9]=[C:8]([CH3:10])[CH:7]=[C:6]([CH3:11])[C:5]=1[CH3:12].N1C(C)=CC=C(C)[C:14]=1C>C(C(C)=O)C>[CH3:12][C:5]1[C:6]([CH3:11])=[CH:7][C:8]([CH3:10])=[C:9]([CH3:14])[N:4]=1

Participants

6

Reactant 4

HCID 222AmmoniaHCID 712FormaldehydeHCID 127592,3,5-TrimethylpyridineHCID 151002,3,6-Trimethylpyridine

Product 1

HCID 195622,3,5,6-Tetramethylpyridine

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

When the process of the present invention is performed in the form of a fixed bed, the catalyst of the present invention is packed in a reactor and heated to a reaction temperature. Then, the mixture of methyl ethyl ketone, formaldehyde and ammonia was allowed to proceed through the gas phase catalytic reaction while maintaining the suitable reaction temperature. Thus, a reaction product containing 2,3,5-collidine, 2,3,6-collidine and 2,3,5,6-tetramethylpyridine is obtained.

Workup

  1. customthe catalyst of the present invention is packed in a reactor
  2. temperatureheated to a reaction temperature
  3. customto proceed through the gas phase catalytic reaction
  4. temperaturewhile maintaining the suitable reaction temperature

Sources & evidence

ORD record
ord-254618eaff4c40ff8b7ec8bd0edea3db
Source dataset
uspto-grants-2002_12
Patent number
US06495695B2

Reaction notes

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