Sodium Hydroxide → Ibandronate Sodium Anhydrous

Participants

Reaction Steps

A solution of amorphous ibandronic acid (5 g) in water (30 ml) was stirred at room temperature. Aqueous sodium hydroxide (0.63 g NaOH in 20 mL water) was added, and the reaction mixture was stirred at room temperature for an additional 1 hour. The solution was evaporated until dry. Hexanes (100 ml) were added to the residue and stirred for 16 hours at room temperature. The precipitate was isolated by vacuum filtration, washed with hexanes (1×50 ml), and dried in a vacuum oven at 50° C. for 45 hours to obtain 5.1 g of amorphous ibandronate sodium.

Provenance & Evidence