N-(4-chlorobenzyl)-7-methyl-2-(4-morpholinylmethyl)-4-oxo-4,7-dihydrothieno(2,3-b)pyridine-5-carboxamide → Thieno(2,3-b)pyridine-5-carboxamide, N-((4-chlorophenyl)methyl)-4,7-dihydro-7-methyl-2-(4-morpholinylmethyl)-4-oxo-, hydrochloride (1:1)

Participants

Reaction Steps

N-(4-chlorobenzyl)-7-methyl-2-(4-morpholinylmethyl)-4-oxo-4,7-dihydro-thieno[2,3-b]pyridine-5-carboxamide (1.50 g) from Example No. 36 is dissolved in methanolic HCl (50 mL) and concentrated in vacuo. The resulting off-white solid is recrystallized from methanol/ethanol to yield 1.458 g (90%) of the title compound as a white solid. Physical characteristics are as follows:

Provenance & Evidence