HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → HCID 22568978, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Methyl{4-[4-(1-benzyloxycyclopropyl)-3-methyl-phenylethynyl]-phenyl}-acetate | HCID 86585924 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 22568978 | HCID 22568978 | — |
Reaction Steps
Using General Procedure E; [4-(1-isopropoxycyclopropyl)-3-methyl-phenylethynyl]-trimethylsilane (Intermediate 80, 250.0 mg, 0.87 mmol) in 8 methanol (10 mL) was treated with potassium carbonate (100.0 mg, 0.72 mmol) and stirred overnight at ambient temperature. The crude alkyne (180 mg, 98%) was used directly in the next reaction.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06495552B2 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-c600d059a7d64b138c8e073f90c77652 |
| Source note | uspto-grants-2002_12 |