HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 1-(1-Ethoxycyclopropyl)-4-ethynyl-2-tert-butylbenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | [4-(1-Ethoxycyclopropyl)-3-tert-butyl-phenylethynyl]-trimethylsilane | HCID 22568955 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-(1-Ethoxycyclopropyl)-4-ethynyl-2-tert-butylbenzene | HCID 22568875 | — |
Reaction Steps
Using General Procedure E; [4-(1-ethoxycyclopropyl)-3-tert-butyl-phenylethynyl]-trimethylsilane (Intermediate 111, 215.0 mg, 0.69 mmol) in methanol (10 mL) was treated with potassium carbonate (80.0 mg, 0.58 mmol) and stirred overnight at ambient temperature. The crude alkyne, 169 mg, was used directly in the next reaction.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06495552B2 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-82657184de4343e68fbfd878505af69b |
| Source note | uspto-grants-2002_12 |