HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 1-(4-Ethynylphenyl)-cyclopropyl-dipropylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Dipropyl-[1-(4-trimethylsilanylethynylphenyl)-cyclopropyl]-amine | HCID 22568945 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-(4-Ethynylphenyl)-cyclopropyl-dipropylamine | HCID 22568912 | — |
Reaction Steps
Using General Procedure E; dipropyl-[1-(4-trimethylsilanylethynyl-phenyl)-cyclopropyl]-amine (Intermediate 122, 45.0 mg, 0.14 mmols) in methanol (5 mL) was treated with potassium carbonate (50.0 mg, 0.37 mmol) and stirred overnight at ambient temperature. The crude alkyne (34 mg, 100%) was used directly in the next reaction.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06495552B2 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-29609f14c612404ea5046e009626a312 |
| Source note | uspto-grants-2002_12 |