HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → HCID 10269185, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Methyl(4-{4-[(cyclopropyl-ethyl-amino)methyl]-3-methyl-phenylethynyl}-phenyl)-acetate | HCID 18340273 | — |
| Reactant | Acetonitrile--water (1/1) | HCID 18373917 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 10269185 | HCID 10269185 | — |
Reaction Steps
Using General Procedure I; a solution of methyl (4-{4-[(cyclopropyl-ethyl-amino)-methyl]-3-methyl-phenylethynyl}-phenyl)-acetate (Compound 129, 140.0 mg, 0.39 mmol) in ethanol (5 mL) and tetrahydrofuran (5 mL) was treated with NaOH (360.0 mg, 9.0 mmols, 3.0 mL of a 3N aqueous solution) and stirred overnight at room temperature. Work-up followed by HPLC (Partisil-10 pac 10% H2O—CH3CN) afforded the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06495552B2 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-0d86f9803fc44013b5abe2ad78ed6d01 |
| Source note | uspto-grants-2002_12 |