Isobutylamine → HCID 18341187, compound

HRID 2299535Notes

Reaction equation

HRID 2299535 reaction equation
CO[C:3](=[O:22])[C@H:4]([CH:19]([CH3:21])[CH3:20])[NH:5][C:6](=[O:18])[CH:7]([CH3:17])[NH:8][C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[C:11]([Cl:16])[CH:10]=1.[CH2:23]([NH2:27])[CH:24]([CH3:26])[CH3:25]>CO.ClCCl>[CH2:23]([NH:27][C:3](=[O:22])[C@H:4]([CH:19]([CH3:20])[CH3:21])[NH:5][C:6](=[O:18])[CH:7]([CH3:17])[NH:8][C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[C:11]([Cl:16])[CH:10]=1)[CH:24]([CH3:26])[CH3:25]

Participants

4

Reactant 2

HCID 6558IsobutylamineHCID 9906254HCID 9906254, compound

Product 1

HCID 18341187HCID 18341187, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

Following General Procedure H above and using N-[N-(3,4-dichlorophenyl)-D,L-alanyl]-L-valine methyl ester (from Example 1 above) and isobutylamine (Aldrich), the title compound was prepared as a oil. The reaction was monitored by tic (Rf=0.3 in 10% methanol/dichloromethane).

Sources & evidence

ORD record
ord-2199f2f352fa43779eb8bdf7eeec7d8a
Source dataset
uspto-grants-2002_12
Patent number
US06495693B2

Reaction notes

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