2-(3,4-Dichloro-phenylamino)-propionic Acid → HCID 21969910, compound

HRID 2299540Notes

Reaction equation

HRID 2299540 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][CH:10]([C:12]([OH:14])=O)[CH3:11])[CH:5]=[CH:6][C:7]=1[Cl:8].Cl.[CH3:16][O:17][C:18](=[O:33])[C@H:19]([CH2:21][CH2:22][CH2:23][CH2:24][NH:25][C:26]([O:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:27])[NH2:20]>>[CH3:16][O:17][C:18](=[O:33])[C@H:19]([CH2:21][CH2:22][CH2:23][CH2:24][NH:25][C:26]([O:28][C:29]([CH3:31])([CH3:30])[CH3:32])=[O:27])[NH:20][C:12](=[O:14])[CH:10]([CH3:11])[NH:9][C:4]1[CH:5]=[CH:6][C:7]([Cl:8])=[C:2]([Cl:1])[CH:3]=1

Participants

3

Reactant 2

HCID 69164262-(3,4-Dichloro-phenylamino)-propionic AcidHCID 16218818L-Lysine, N6-[(1,1-dimethylethoxy)carbonyl]-, methyl ester, hydrochloride (1:1)

Product 1

HCID 21969910HCID 21969910, compound

Procedure

Following General Procedure D and using N-(3,4-dichlorophenyl)-D,L-alanine (from Example A above) and Nε-BOC-L-lysine methyl ester hydrochloride (Bachem), the title compound was prepared as a oil. The reaction was monitored by tlc (Rf=0.23 in 45% ethyl acetate/hexanes).

Sources & evidence

ORD record
ord-2012ba7a06794388b69f6f9fa12cedfa
Source dataset
uspto-grants-2002_12
Patent number
US06495693B2

Reaction notes

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