HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → N-[N-(3,5-dichlorophenyl)-D,L-alanyl]-(S)-2-aminohexan (N-methyl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | N-tert-Butoxycarbonyl-L-norleucine | HCID 2733747 | — |
| Reactant | N-(3,5-dichlorophenyl)-D,L-alanine | HCID 15484844 | — |
| Reactant | l-Norleucine n-methyl amide | HCID 18341173 | — |
| Product | N-[N-(3,5-dichlorophenyl)-D,L-alanyl]-(S)-2-aminohexan (N-methyl)-amide | HCID 131721932 | — |
Reaction Steps
Following General Procedure D and using N-(3,5-dichlorophenyl)-D,L-alanine and L-norleucine N-methyl amide (prepared by coupling BOC-L-norleucine (Bachem) with methylamine (Aldrich) using General Procedure E, followed by removal of the BOC group using General Procedure F), the title compound was prepared. The reacticon was monitored by tlc (Rf=0.25 in 3% methanol/dichloromethane) and purification of this compound was by thin layer chromatography with 3% methanol/dichloromethane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06495693B2 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-3d16b1a6e9ba48db9831babdea997ac6 |
| Source note | uspto-grants-2002_12 |