2-Amino-2-phenylethan-1-ol → HCID 131721934, compound

HRID 2299559Notes

Reaction equation

HRID 2299559 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][CH:10]([C:12]([OH:14])=O)[CH3:11])[CH:5]=[CH:6][C:7]=1[Cl:8].[C:15]1([C@@H:21]([CH2:23][OH:24])[NH2:22])[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][CH:10]([C:12]([NH:22][C@@H:21]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH2:23][OH:24])=[O:14])[CH3:11])[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

3

Reactant 2

HCID 1347972-Amino-2-phenylethan-1-olHCID 69164262-(3,4-Dichloro-phenylamino)-propionic Acid

Product 1

HCID 131721934HCID 131721934, compound

Procedure

Following General Procedure E and using N-(3,4-dichlorophenyl)-D,L-alanine (from Example A above) and (S)-(+)-2-phenylglycinol (Aldrich), the title compound was prepared as a solid (mp=66-70° C.). The reaction was monitored by tlc on silica gel (Rf=0.25 in 5% methanol/methylene chloride) and purification was by flash column chromatography (silica gel using 5% methanol/methylene chloride as eluent).

Workup

  1. customThe reaction was monitored by tlc on silica gel (Rf=0.25 in 5% methanol/methylene chloride) and purification

Sources & evidence

ORD record
ord-a140794ee30a420aa504b4ae4632bf6c
Source dataset
uspto-grants-2002_12
Patent number
US06495693B2

Reaction notes

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