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The synthesis of 2,6-NDC typically includes several steps. In a typical synthesis, orthoxylene and butadiene are reacted over an alkali metal or other catalyst to yield a 5-orthotolylpentene (5-OTP) alkenylation product. The 5-OTP is then cyclized over an acid catalyst to yield 1,5 dimethyltetralin (1,5-DMT). The 1,5 DMT is dehydrogenated over a noble metal or some other dehydrogenation catalyst to yield 1,5-dimethylnaphthalene(1,5-DMN), which is subsequently isomerized to produce 2,6-dimethylnaphthalene (2,6-DMN).

1. customThe synthesis of 2,6-NDC typically includes several steps